Lifestyle, Supplements

How to support longevity and young look and slow down aging of organs? 14 best antiaging supplements

People always desire to live forever , or at least to feel and look young for the longest period of their lives. Human lifespan depends on variety of factors, ranging from genetics to lifestyle. Modern lifestyle contributes to the fact, that nowadays we live much longer than generations before us. Lets take a look in the 1950, when , because of diseases, not too many people were living until retirement age. Even if we live longer than our ancestors , it seems like for people it is not enough. There are some methods and supplements today that we can use so we can slow down aging of our organs, look younger and live a bit longer.



One of the great methods to stay healthy and boost imunity is wim hof method. You will gain many physical and mental benefits by practising this method. The core of this method is manipulating our own bodies and central nervous system and pushing boundaries and our own abilities. This happens by cold therapy and breathing exercises. According to the portal Wimhofmethod , this method strenghtens immune system. Wim hof claim you can you can run a few miles on ice barefoot withut worrying about feeling sick and having a fever next day.

Wim hof method works as a prevention, but also supports healing processes in the body , lowers inflammation , improves sleep quality and lowers blood pressure. When it comes to mental aspect, wim hof method helps reduce impact of stress on people, supports endorphins release and helps with overall well-being.It is also known that, for example blood pressure, contributes to shortening of lifespan of a person, as well as inflammation.


  These days, everybody can choose from variety of methods of eating. Fasting is becoming very popular, especially intermittent fasting. Intermittent fasting is usually used when people are trying to loose weight, but it also has many health benefits. More and more studies are showing that proper fasting not only improves health but also prolongs life. Scientists also think that intermittent fasting has an impact on circadian rhytm and sleep, and very positively impacts microbiome. Especially gut bacteria are very important for wellbeing and good mood. You can read more about gut microbiome and its impact here.

  Even if intermittent fasting can look uncomfortable, people in the past did not have sedentary lifestyle and did not eat three meals per day. Human body is created in a way that it can be physically and mentally active for many hours without consuming food. Intermittent fasting is basically at least 12- hour fast, but fasting can be much longer- even a couple of weeks.

Intermittent fasting helps to combat diseases and support healing processes in the body. It acts as a prevention in diabetes, cancer, cardiovascular diseases and Alzheimer disease. Intermittent fasting works even further and supports mitochondrial health and cell regeneration on DNA level. Studies have shown that regular fasting helps mitigate consequences of oxidative stress, as well as inflammatory processes. In some organisms, there was proven that intermittent fasting helps slow down cell aging, extend lifespan and increases body resistance. It also has an anti-aging effect on brain. Studies have shown that , because of fasting , cognitive functions remain very high quality in the elderly. Intermittent fasting cause a change in body´s hormonal levels , cells start regeneration process and also there are some ganges in gene expression. When it comes to hormones, Intermittent fasting increases amount of growth hormone in the body. Growth hormone helps the body with shredding the fat while maintaining muscle. In the elderly people, lack of growth hormone can cause increase in fat storages and skin thinning. Large benefit of intermittent fasting is that it does not have side effects like many drastical diets that can potencially harm people´s health.


 There are many debates about calorie intake, when should people consume calories , in what form and what quantity. Many people think that calorie restriction is only good for loosing weight. But caloric restriction can help  in many other ways. It works as a prevention against cardiovascular diseases and cancer, lowers blood pressure, regulates cholesterol and glucose. Besides that, some studies have shown that caloric restriction can extend lifespan in some species and lowers the risk of death caused by an old age. Caloric restriction can prolong also human´s life , even after 6 months of caloric restriction, but more studies are needed to support this claim.The disadvantage of caloric restriction is that not only fat but also muscle is being wasted and bones are getting less dense. People over 60 years old should be aware of caloric restriction method.


Nicotinamide adenine dinucleotide (NAD) is coenzyme, that plays role in many enzymatic reactions and cell processes in the body. It plays extremely important role in mitochondrial function, helps with regulating gene expression, maintaining telomeres and regeneration of DNA. It also regulates cell aging and cell death. The older we get, the lower levels of NAD we have in our bodies, which comes with health consequences such as cognitive impairments. Maintaining right amount of NAD in the body, for example with supplements, is important for maintaining cognitive and neuromuscular functions as well. Studies also show that NAD helps support metabolism and helps with maintaining optimal weight , which contributes to anti-aging by itself. How to maintain optimal levels of NAD? You can either use supplements and you can also use techniques sucha s caloric restriction and intermittent fasting.



Collagen is a Protein in our body, it is also the building block of our muscles, bones, tendons and ligaments, smaller amounts are in our teeth and vessels. Collagen Plays a major role in a many of vital functions in our body, most common known is the ability that keeps our skin tight. There are 16 types of Collagen, witch help you with these vital functions.  With increasing age our bodies produce smaller amounts and the quality decreases. Supplementing Collagen and maintaining an adequate level is helpful not only to keep us young looking but also,  as many studies have shown Collagen helps Antioxidants with their proceses inside out bodies and never the last Colagen also helps us to fight of disseases like osteoarthritis. To keep a healthy level of Collagen in our bodies, the number  one rule is an well balanced diet where the goal is to lower as much added sugars as we can. Consuming large quantities of sugar keeps our skin weakened damage like visible wounds, these take longer to heal with insufficient amounts of Collagen. Smoking and staying too long on the sun reduces you level of Collagen, on the other hand you can increase you levels with supplements and diet. Your diet should definetly include quality broth and gelatina, try to go for some gummy bears  :).



Telomers are the terminal parts of chromosomes that play a key role in cell aging and affect cell responses to stress. They prevent cell damage and thus various diseases, such as cardiovascular disease, cancer or aging-related diseases. The more the cell divides,the more  Telomers shorten. Oxidative stress also contributes to faster telomere shortening. When the telomeres can no longer shorten,  cell stops dividing, it becomes inactive and gradually dies. However, telomeres protect against the shortening with the help of the enzyme telomerase, which in the end chromosomes  bads together other telomere sequences. However, telomerase is only found in some cell types,that means that the rest are left to age and shorten.

Telomere Lenght, acording to some studies, also affects an individual’s lifestyle(other factors are Telomerase and age).For example, proper diet (foods high in antioxidants) can slow down the process of telomere shortening, and thus aging. On the other hand, smoking or lack of exercise and obesity accelerate telomere shortening. Currently, scientists are intensively researching how The extract of the adaptogenic plant astragalus may contribute to the slowing of telomere shortening. Astralagus extract is most commonly used in Chinese traditional medicine, it acts as an antioxidant and supports the immune system.



Acetyl-L-Carnitine has become the focus of many researchers. The reason being are some studies that show that its long-tem use may slow down cognitive decline, for example in the case of Alzheimers disease. Further studies suggest that Acetyl-l-Carnitine can partialy recover functionality of mitochondia (Mitochondia functions decline with age).

Pyrroloquinoline quinone (PQQ)

Pyrroloquinoline quinone (PQQ) is part of an enzyme called quinoprotein. PQQ plays an important role in metabolic processes in the body, but also in the structural integrity of cells and tissues. High volumes of PQQ are found in many plants, but also in yeast. As far as common foods are concerned, you can find PQQ in some teas, but also peppers, papaya and kiwi. Animal studies have shown that if there was a lack of PQQ in their body, their immune system and metabolism were disrupted and  various abnormalities occurred in their bodies. PQQ supports mitochondrial function, but at the same time works neuroprotective and helps improve cognitive function. The impact of PQQ on humans is still in the process of research, however, research to date has shown that it has antioxidant and  antidiabetic properties and providecs protection against radicals and oxidative stress.



Coenzyme Q10

Coenzyme Q10 is commonly found in the human body, but it is most abundant in the liver, heart, kidneys and in the pancreas. Coenzyme Q10 plays a key role in the proper functioning of mitochondria, it works as an antioxidant and inhibits apoptosis(programmed cell death). Although coenzyme Q10 is common in the human body, as an supplement it is used to treat various diseases, such as cellular metabolism disorders, or to alleviate the impact of oxidative stress. Scientists are currently testing the potential use of coenzyme Q10 in the treatment of neurodegenerative diseases such as Parkinson’s disease. Some studies report that coenzyme Q10 supports and increases the immune system levels of adenosine triphosphate in the body, which is an essential part of cellular metabolism.




N-acetyl-cysteine ​​(NAC) has a number of health benefits, including helping to keep the body  at right levels of glutathione, which is an extremely effective antioxidant. It neutralizes free radicals and thus protects cells from damage. Some studies suggest that regular consumption of NAC (therefore glutathione levels are maintained at an optimum ) help prolong life. In addition, NAC supports cognitive and neurological functions (it also has its use in the field of psychiatry in the treatment of some psychiatric patients), protects against oxidative stress, supports the immune system and acts as a prevention of vascular diseases. Studies suggest that it also detoxifies and protects the body from the effects of toxic substances metals that enter the body from the environment in which we live in.



Alpha-lipoic acid

Alpha-lipoic acid is heavily involved in ongoing metabolic processes in mitochondria. In recent years it is   gaining momentum as an effective antioxidant. It protects against free radicals and also protects the cell membrane by interacting with vitamin C, glutathione and helps recycle vitamin E. It helps to fight the effects of oxidative stress, slows down aging (maintains a youthful appearance of the skin), but also has positive effects during treatment of various diseases, such as cataracts, HIV, protects against neurodegeneration and mitigates the impact radiation. In addition, some studies suggest that it helps fight obesity. Although alpha- lipoic acid naturally forms in our bodies, it is good to maintain optimal levels with an healthy diet or supplementation.


Agmatine sulfate

There are relatively few studies on the effects of agmatine sulfate, but they suggest that regular use of this substance has several health benefits. For example, it helps to reduce excess weight, lowers blood pressure and also helps in the treatment of neuropathic pain or other conditions. Another important  property of agmatine sulfate is that it helps the body to regulate nitric oxide levels, which among other things ensures optimal blood flow through individual parts of the body and is important for health cardiovascular system or immunity. In addition, nitric oxide aids in proper transport signals between neurons. No side effects were observed with long-term use of agmatine sulphate.



Huperzine A

Huperzine A is an alkaloid derived from the plant Huperzia serrata and one of its most important property is the ability to regulate the enzyme acetlycholinesterase. This causes the neurotransmitter to break down acetylcholine (wich is responsible for signal transduction between synapses) to form choline and acetate. Then Choline uses acetylcholine to regenerate. Huperzine A has a neuroprotective effect and slows down the aging of the brain, improves cognitive function and memory skills, to some extent it can reverse their decline and acts as a prevention in diseases affecting the brain, such as Alzheimer’s disease or vascular dementia.



DHEA (dehydroepiandrosterone) is a hormone naturally occurring in the human body, it is also a supplement that can help regulate hormone levels, especially in old age when the level of hormones in the body change significantly. It is not for nothing, that it is called the hormone of youth. It helps to keep you an healthy weight and improves the sexual functions of the individual. DHEA is a precursor for in the production of sexual  hormones, androgens and estrogens. Studies show that the less DHEA a person has in his body, the higher there is a risk of muscle weakness, depression or even shortening of life spam. Among other things, DHEA helps fight obesity, regulates cholesterol levels in the body, as well as production procollagen.



Pregnenolone (C21steroid) is a cholesterol-like hormone within the  group of steroids C21.It acts as an important precursor for all other steroid hormones formed in the adrenal glands, ovaries and testes. Pregnenolone has a neuroprotective effect, supporting cognitive functions

and the ability to learn it helps with the feeling of  overall satisfaction and well-being. It supports the growth of new neurons and especially ,in old age helps to delay the signs of aging.



Fisetin is a nutritional supplement with strong antioxidant effects, which has also been studied.Some of these studies confirmed that Fistein can prolong your life. It is a flavonol belonging to the group of flavonoids and is commonly found in fruit or vegetables, such as cucumbers, strawberries, grapes or apples. In addition to the mentioned antioxidant effects , an anti-inflammatory effect is  shown within Fisetin ,other studies shown that it supports cognitive functions, including memory capabilities.


Hyaluronic acid is a polysaccharide that the human body can produce naturally, while found mainly in the skin or connective tissues. It Helps us to maintain moisture in the skin and prevents its rapid aging. However, it is also used in the form of supplements, whose main task is to support health and youthful appearance of the skin. Hyaluronic acid protects the skin from free radicals, negative influences such as excessive UV radiation or smoking. In addition, it helps in the fight against dermatitis,it accelerates wound healing and tissue regeneration and promotes skin elasticity, also helps with the fight against wrinkles.



You have probably heard about melatonin before, it is a well known supplemen (for example, for regulating the sleep-wake cycle and other circadian rhythms in the body). In addition, it has an immunostimulatory and cytoprotective effect. Studies suggest that maintaining the optimal level of melatonin in the body trought its regular use in the form of a supplement helps to improve sleep quality and protects against neurodegenerative diseases. An advantage of melatonin is also the fact that it promotes the leaching of so-called human growth hormone (GH), which we mentioned above. GH affects the aging process, promotes well-being and improves functionality of the immune system.

MK-677 (research only)

The substance mk-677, also known as Ibutamoren, is currently enjoying a boost in its popularity, although not many researches have been done so far, it is rather an experimental substance intended for scientific purposes. Some studies suggest that the use of mk-677 may, improve sleep quality and promote excretion GH, the growth hormone mentioned in the previous paragraphs.



HOW TO PROLONG YOUR LIFE?  Your lifespan depends on genetics as well, but nutrition, lifestyle, physical activity and overall levels of stress play extremely important role. Some supplements can help prolong life as well, because all of the factors mentioned above are part of a large mosaic that determines how long you will live.

START being in a caloric deficit and focus on bio foods. Start practising Wim Hof method and intermittent fasting. These activities will help you heart, digestive tract and will improve many processes in your body.

As we in BonooBo consider ourselves professionals in a supplement field, I always recommend taking supplements that are backed up by scientific research. Supplements such as collagen, coenzyme Q10 , acetyl-l-carnitine or alpha lipoic acid are nice add-ons that will protect you brain, skin , joints in the long-term.  SPecial place in this list has Astralagus that can slow down the shortening of telomeres- it is a truly useful anti-aging plant .

DISCLAIMER:  The information included in this article is intended for entertainment and informational purposes only. It is not intended nor implied to be a substitute for professional medical advice. Prior to buying anything, check that it is compliant where you live with your current government laws.

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